VWF neutralization by anti-VWF Abs reduces myocardial I/R injury in WT and Adamts13^−/− mice. (A) Quantification of the infarct size (n = 7-9/group). Each dot represents a single mouse. Horizontal bars indicate mean values. (B) Plasma cardiac TnT levels (n = 7-9/group). Data are means ± SEM. Two-way ANOVA showed that the interaction of genotype and treatment with the VWF inhibitor was significant (P = .017; F = 6.56). NS indicates nonsignificant.