Generation 1.0 dendrimer and polymyxin B inhibit clotting of whole human blood initiated by polyP but not by tissue factor. Thromboelastometry (ROTEM) profiles are given for clotting of freshly drawn, nonanticoagulated whole human blood initiated by long-chain polyP (A-B) or tissue factor (C-D), in the presence of generation 1.0 dendrimer (A,C) or polymyxin B (B,D). The x-axis represents time from addition of clotting trigger; and y-axis, amplitude of clot strength.