CYT107 induces increases in T cells in the peripheral blood but does not affect NK cells or B cells. (A) Absolute CD3 counts. (B) Ratio CD3 count/baseline. (C) Absolute CD4 counts. (D) Ratio CD4 count/baseline. (E) Absolute CD8 counts. (F) Ratio CD8 count/baseline. (G) Absolute B-cell counts. (H) Ratio B-cell count/baseline. (I) Absolute NK-cell counts. (J) Ratio NK count/baseline. Absolute counts are shown for individual patients. The ratios (mean ± SEM) are shown for each cohort and are calculated using as a baseline value the mean of the pretreatment and day 0 values. The shaded area represents the CYT107 treatment interval (injections were given once a week as described in “Results”). (A,C,E,G,I) The horizontal line indicates the lower limit of normal.