Administration of CYT107 enhances TCR diversity. (A) Evolution of the mean combinatorial diversity (hTRβ) over time. Individual patients and the mean diversity are shown. The shaded area on each graph represents the CYT107 treatment interval. For patient 14-303, only the last study time point was available for analysis because of profound lymphopenia before that sample. (B) Relationship over time between T-cell counts and hTRβ (NDL representation). Most patients shift from NDL1 (low CD3/low diversity) toward NDL2 (low CD3/normal diversity) after treatment with CYT107. Individual patients are shown. Squares, circles, and triangles represent patients in the 10-, 20-, and 30-μg/kg cohorts, respectively. (C) The image represents a 3D graph of immune combinatorial diversity at each studied time point (pre, D0, D28, D77) after treatment with CYT107 in representative patient 14-207. Each peak represents the rearrangement between a V gene family and a J segment. V families are represented on the x-axis. J segments are represented on the y-axis. The intensity of these rearrangements is represented on the z-axis, varying between 0 and 5.