Activation of coagulation in sickle cell mice. (A) Plasma TAT levels in WT (open bar; n = 6) and BERK (filled bar; n = 16) mice (both on a similar mixed genetic background). *P < .05. (B) Plasma TAT levels in WT^BM (open bar) or BERK^BM (filled bar) mice injected with either a rat anti–mouse TF (n = 5 for WT^BM; n = 14 for BERK^BM) or control rat IgG antibodies (n = 8 for WT^BM; n = 14 for BERK^BM). (C) Plasma TAT levels in TW^AA (open bar) or TW^SS (filled bar) mice injected with either a rat anti–mouse TF (n = 6 for TW^AA; n = 7 for TW^SS) or control rat IgG antibodies (n = 7 for TW^AA; n = 11 for TW^SS). Asterisks directly above the bars indicate statistically significant difference compared with WT^BM or TW^AA controls within the same treatment: **P < .01; and ***P < .001.