Inflammation and endothelial cell activation in sickle cell mice. Plasma levels of various inflammatory mediators and markers of endothelial cell activation in: WT (open bar; n = 12) and BERK (filled bar; n = 22) mice (left column); WT^BM (open bar; n = 5-8) and BERK^BM (filled bar; n = 14) mice (middle column) treated with 1H1 or IgG antibodies; TW^AA (open bar; n = 6 or 7) and TW^SS (filled bar; n = 7-11) mice (right column) treated with 1H1 or IgG antibodies. Asterisks directly above the bars indicate statistically significant difference compared with wild-type controls within the same treatment: *P < .05; **P < .01; and ***P < .001.