Effect of ANXA2 expression on EFS and OS. OS (A) and EFS (B) for our patients (HM group; n = 247) and the LR group (n = 701). All patients were treated with high-dose chemotherapy and autologous stem cell transplantation. Two groups of patients with low (ANXA2^low, black curve) and high (ANXA2^high, gray curve) ANXA2 expression could be delineated. The OS was significantly superior for low ANXA2 expression (HM group, P < .001 and LR group, P < .001). The same held true for EFS in the HM group (P = .004) and the LR group (P < .001).