Clinical course of a patient with high-risk MM. The clinical course of a single patient (MC1130) studied throughout the entire disease course is shown. Red line indicates the quantitative IgA level detected and units are shown on the left y-axis. Blue line indicates the free light chain ratio detected with units shown on the right y-axis. Alternating color regions indicate type and durations of treatment received during each interval. Red arrows highlight the time points at which BM aspirates were analyzed, the green arrow indicates the time of collection of the terminal PCL sample from peripheral blood. Dx indicates diagnosis; Rem, remission: R1, relapse 1; R2, relapse 2; R3, relapse 3; and R4, relapse 4. The assays performed at each time point are indicated under their representative arrows.