Depletion of CD4 T cells leads to depletion of both FDC and FRC networks in both RMs and SMs. (A) Immunofluorescent staining of CD4, CD35, desmin, and IL-7 in LNs from RMs and SMs before and after CD4⁺ T-cell depletion, showing that CD4 T-cell depletion leads to depletion of FRC and FDC networks and loss of IL-7 production in both SMs and RMs. Dotted circles represent the position of B-cell follicles. (B) Immunofluorescent staining of desmin, a marker for both FRCs and FDCs in LNs from RMs and SMs before and after CD8 T-cell depletion, showing the preservation of FDC and FRC networks after CD8⁺ T-cell depletion in both RMs and SMs. Dotted circles represent the position of B-cell follicles.