Depletion of CD4 T cells correlates with depletion of FRC and FDC networks in HIV-1 infection. (A) Immunohistochemical staining of CD4, CD35, and desmin in LNs from uninfected and chronically HIV-1–infected subjects, showing the depletion of CD4 T cells in B-cell follicles and T-cell zone correlates with depletion of FDCs and FRCs in B-cell follicles and T-cell zone. Dotted circles represent the position of B-cell follicles. Original magnification ×200. (B) Correlation between the percent area of stromal cells and peripheral blood CD4 T-cell counts (cells/μL) before (top panel) and after (bottom panel) the initiation of ART.