FOXO1 mutations correlate with reduced survival in DLBCL. (A) Kaplan-Meier curves of OS in a cohort of 193 de novo DLBCL patients uniformly treated with R-CHOP, comparing FOXO1 wild-type (solid black) vs FOXO1 mutant (dotted grey) subgroups. Patients with a mutation in FOXO1 had lower OS rates relative to patients without a mutation (log-rank, P = .037). (B) Kaplan-Meier curves of OS in a cohort of 97 low-risk R-IPI categories (very good and good; IPI scores 0-2) DLBCL patients uniformly treated with R-CHOP, comparing FOXO1 wild-type (solid black) vs FOXO1 mutant (dotted grey) subgroups. Patients with a mutation in FOXO1 had lower OS rates relative to patients without a mutation (log-rank, P = .003).