Genetic interaction between SLX4 and nucleases in the response of MMC and CPT. (A) MMC sensitivity in RA3331/E6E7/hTERT cell lines expressing the empty vector and WT SLX4 after knocking-down indicated nucleases. (B) CPT sensitivity in RA3331/E6E7/hTERT cell lines expressing the empty vector and WT SLX4 after knocking down indicated nucleases. (C-D) The efficiency of knockdown of XPF and MUS81 was measured in whole cell extracts by Western blotting. The siRNA against Luciferase (siLuc) was used as a negative control. (A-B) The error bars represent SD from 3 replicates.