Analysis of CPT and PARP inhibitor sensitivity of FA fibroblast cell lines. (A) CPT sensitivity assay of the indicated FA fibroblast cell lines. (B) PARP inhibitor sensitivity assay of the indicated FA fibroblast cell lines. All cell lines have been transduced with HPV E6E7. Indicated FA cell lines were treated in triplicate with increasing concentrations of CPT (0-16nM) and PARP inhibitor (0-10μM). After 8 days in culture, the cell number was determined with Coulter counter. The number of cells at each drug concentration was divided by the number of cells in the untreated sample to calculate the percentage of cell survival. The error bars represent SD from 3 replicates.