Donor HPC TF triggers systemic thrombin generation in a model of HPC transplantation. Anesthetized mice were given 2 × 10⁵ primary control HPCs, HPC^ΔTF HPCs, or vehicle (100 µL sterile HBSS) via a portal vein injection. (A) Serum levels of ALT activity and (B) plasma TAT were determined 15 min after HPC injection. Data are expressed as mean +SEM. *Significantly different from control mice injected with vehicle (P < .05). ^#Significantly different from control mice injected with control primary HPCs (P < .05). n = 6 to 7 mice/group.