Molecular course after imatinib discontinuation. Comparison of molecular relapse kinetics between the 2 instances of imatinib discontinuation in patients with treatment reintroduction. (A) Example of similar molecular relapse kinetics. (B) Example of second molecular relapse kinetics slower than the first. (C) Example of second molecular relapse kinetics faster than the first. (D) Kaplan-Meier estimates MMR (gray curve) and CMR (black curve) after a second discontinuation of imatinib in patients with chronic myeloid leukemia.