aDabi-Fab does not induce clotting activity (A) Lack of binding of thrombin substrates to aDabi-Fab in SPR. (B) Lack of thrombotic activity of aDabi-Fab in prothrombin-deficient plasma when supplemented with small amounts of prothrombin. Data are expressed as mean ± SD, n = 3. (C) Lack of effect of Fab on fibrinogen conversion to fibrin measured as FPA generation in plasma in vitro. Data shown as mean of triplicate determinations. (D) Lack of effect of aDabi-Fab to induce further thrombin generation in plasma, in contrast to Feiba, which elevated thrombin generation. Data mean of 5 determinations. (E) Effect of aDabi-Fab (3 mg/mL) and SFLLRN (2µM) or a combination on platelet aggregation in human platelet rich plasma. Data expressed as mean ± SD, n = 3.