aDabi-Fab reverses the anticoagulative effects of dabigatran in vivo. The effect of a continual infusion of dabigatran (squares, solid line) given as a bolus loading dose (0.3 µmol/kg) and continual infusion (0.1 µmol/kg/h). aDabi-Fab (circles, solid line, 0.3 µmol/kg) was given as a single bolus at t = 0. Thrombin time (A) and aPTT (B) were measured at different time points over 30 minutes after the injection of aDabi-Fab. Data represented as mean ± SE, n = 4-6 per group.