Figure 2
Figure 2. FibγΔ5 exhibit a distinct survival advantage over wild-type mice in S. aureus septicemia over a wide range of bacterial doses and through ClfA-dependent and ClfA-independent mechanisms. (A–D) Survival profile of wild-type and FibγΔ5 mice (N = 10 pairs) following intravenous injection with Newman strain S. aureus at the indicated doses. (E–F) Survival profile of wild-type and FibγΔ5 cohorts (N = 12 pairs) following intravenous administration of the community-associated strain of S. aureus USA300 at the indicated doses. Comparative analysis of survival in control and FibγΔ5 mice challenged in parallel with either (G) 2.4 × 108 CFUs intravenously or (H) 3.3 × 108 CFUs intravenously. ClfA-deficient derivative of S. aureus Newman. Survival was compared using the Kaplan-Meier log rank analysis.

FibγΔ5 exhibit a distinct survival advantage over wild-type mice in S. aureus septicemia over a wide range of bacterial doses and through ClfA-dependent and ClfA-independent mechanisms. (A–D) Survival profile of wild-type and FibγΔ5 mice (N = 10 pairs) following intravenous injection with Newman strain S. aureus at the indicated doses. (E–F) Survival profile of wild-type and FibγΔ5 cohorts (N = 12 pairs) following intravenous administration of the community-associated strain of S. aureus USA300 at the indicated doses. Comparative analysis of survival in control and FibγΔ5 mice challenged in parallel with either (G) 2.4 × 108 CFUs intravenously or (H) 3.3 × 108 CFUs intravenously. ClfA-deficient derivative of S. aureus Newman. Survival was compared using the Kaplan-Meier log rank analysis.

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