A deficiency in platelet number or loss of platelet function, including a loss of the platelet fibrinogen receptor αIIbβ3, does not present a survival advantage compared to that observed in FibγΔ5mice. (A) Survival analysis of platelet-depleted and control mice (N = 10 pairs) following an intravenous injection of 2.7 × 108 CFUs of Newman strain S. aureus. Mice were treated with either an antiplatelet antibody or a control antibody prior to bacteremia challenge. Note that platelet-depleted mice had a significantly shorter survival profile than control mice. (B) Survival analysis of mice deficient in the platelet integrin receptor subunit αIIb and control mice following intravenous injection of 2 × 108 CFUs Newman strain S. aureus. (C) Survival analysis of control mice (N = 11) and mice deficient in PAR-4 (N = 10) following an intravenous injection of 2.2 × 108 CFUs of Newman strain S. aureus. Survival was compared using the Kaplan-Meier log rank analysis.
