Figure 4
Figure 4. Host prothrombin, but not host TF, PAR-1, or fXIII, drives virulence following intravenous S. aureus infection. (A) Survival analysis of wild-type and fIIlow mice (carrying ∼10% normal level of prothrombin) following intravenous infection with 2 × 108 CFUs of Newman strain S. aureus (N = 10 pairs). (B) Survival analysis of control mice (N = 14) and mice expressing low levels of TF (N = 12) following intravenous infection with 2 × 108 CFUs of Newman strain S. aureus. (C) Survival analysis of wild-type and PAR-1−/− mice (N = 12 pairs) following intravenous infection with 2 × 108 CFUs of Newman strain S. aureus. (D) Survival analysis of fXIII+/− (N = 11) and fXIII −/− mice (N = 10) following intravenous infection with 2 × 108 CFUs of Newman strain S. aureus. Survival was compared using the Kaplan-Meier log rank analysis.

Host prothrombin, but not host TF, PAR-1, or fXIII, drives virulence following intravenous S. aureus infection. (A) Survival analysis of wild-type and fIIlow mice (carrying ∼10% normal level of prothrombin) following intravenous infection with 2 × 108 CFUs of Newman strain S. aureus (N = 10 pairs). (B) Survival analysis of control mice (N = 14) and mice expressing low levels of TF (N = 12) following intravenous infection with 2 × 108 CFUs of Newman strain S. aureus. (C) Survival analysis of wild-type and PAR-1−/− mice (N = 12 pairs) following intravenous infection with 2 × 108 CFUs of Newman strain S. aureus. (D) Survival analysis of fXIII+/− (N = 11) and fXIII −/− mice (N = 10) following intravenous infection with 2 × 108 CFUs of Newman strain S. aureus. Survival was compared using the Kaplan-Meier log rank analysis.

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