Plasma levels of BAG6 and NKG2D ligands are elevated in CLL patients and increase with advanced Binet stage. (A-D) Plasma levels of NKp30-ligand BAG6 and NKG2D ligands (MICB, ULBP2, MICA) were measured by ELISA in healthy controls (age-matched) and CLL samples. A comparison of healthy vs CLL samples and a comparison of CLL samples (mean and standard error of the mean) from patients with Binet stage A, B, or C are depicted. Significant differences are indicated (two-tailed, unpaired Mann-Whitney U test).