Role of the WASp-WIP interaction in the formation of stable podosomes. WIP regulates the activation of WASp at specific sites such as podosomes by stabilizing the WASp autoinhibited conformation, retaining WASp at sites of active actin polymerization in the proximity of stimulatory binding partners and protecting WASp from degradation. In EVH1-mutated WASp, all 3 of these mechanisms are disrupted. See “Discussion” for further details.