KSHV vIL-6 induces D6 expression in LECs. (A) Transfection of HDLECs with KSHV-encoded vIL-6 vector results in high vIL-6 expression (by QPCR). (B) Transfection with the vIL-6 vector, but not control plasmid vector, significantly upregulates D6 expression in HDLECs. (C) Transgenic expression of vIL-6 in mice under the control of the MHC-I promoter results in the overexpression of D6 in mouse lymph nodes but not spleen.