Hsp70 ATPase activity inhibition affects proliferation and growth of tumor xenografts. (A) Graph representing tumor volumes at indicated days during the experiment for the 4 groups of mice indicated (5 mice/group). Two groups of mice were subcutaneously injected with 6 × 107 Daudi lymphoma cells and another 2 groups with 4 × 107 Raji lymphoma cells (day 1). When tumors reached 50 mm3 (day 12), Myr (20 mg/kg) or DMSO in a volume of 50 μL was injected directly into the tumors at 12, 15, 18, and 21 days. Tumors were measured on the day of the injection and 3 days after the last injection. (*P < .05). (B) Xenograft tumors were weighed. (C) Total lysates from tumors were analyzed by Western blotting and tested with indicated antibodies (*P < .05).
