c-Myc overexpression–associated chromosome 15 trisomy in monoclonal T-cell lymphoma. (A) Tcrβ diversity in 12 independent Hdac1^Δ/ΔHdac2^Δ/+ lymphomas analyzed by Southern blot, using a Jβ2 region-specific probe, g.l. = germline Tcrβ. (B) Representative CGH plots of 6 independent lymphomas with indicated genotypes. (C) c-Myc levels in WT thymocytes and Hdac1^Δ/ΔHdac2^Δ/+ tumors analyzed by qPCR. (D) c-Myc protein levels in wild-type thymi as well as Hdac1^Δ/Δ, Hdac1^+/Δ;Hdac2^Δ/Δ and Hdac1^Δ/Δ;Hdac2^+/Δ lymphoma cell lines. Bottom panel shows quantification of c-Myc protein levels relative to tubulin. WT, wild type.