Kaplan-Meier analysis of survival in MDS patients stratified according to SF3B1 mutation status. (A) Overall survival, defined here as the time (in months) between the date of diagnosis and the date of death (for patients who deceased) or last follow-up (for censored patients). (B) Leukemia-free survival (LFS), defined as the time between the date of diagnosis and the date of leukemic transformation (for patients who progressed to AML) or last follow-up. (C) Event-free survival (EFS), defined as the time between the date of diagnosis and the date of first event (death or leukemic transformation) or last follow-up. Vertical tick marks indicate right-censored patients. Reproduced from Malcovati et al.²⁶