Kaplan-Meier curves of EFS according to DI. Six-year EFS estimates: 82% (DI < 1.16), 90% (DI 1.16 to <1.24), 94% (DI ≥ 1.24). HR DI 1.16 to <1.24 vs DI < 1.16: 0.56; HR (DI ≥ 1.24 vs DI < 1.16): 0.35; Wald test of heterogeneity: P = .03. Considered as 3-ordered categorical variable (DI < 1.16 vs DI 1.16 to <1.24 vs DI ≥ 1.24), the estimated HR was 0.58 (95% CI, 0.38 to 0.87); Wald test for linear trend: P = .009.