Positive predictive value for myeloid neoplasm of the most frequently mutated genes. (A) Distribution and positive predictive value of the most frequently mutated genes. The upper bars indicate positive predictive values for myeloid neoplasm: blue indicates the predictive value according to standard diagnostic approach, whereas lavender depicts the predictive value when accounting for ICUS with mutation pattern highly specific for myeloid neoplasm as true positive cases. The lower bars report the distribution of mutated genes according to the final diagnosis of standard workup (pink, myeloid neoplasm; orange, ICUS; red, other cytopenia). (B) Distribution and positive predictive value of mutations in TET2, ASXL1, and DNMT3A as isolated mutations or comutation patterns (bar colors as in panel A). (C) Positive predictive value of the most frequent mutated genes associated with TET2, ASXL1, and DNMT3A mutations (bar colors as in panels A and B).