Probability of progression to myeloid neoplasm of patients receiving a provisional diagnosis of ICUS, according to mutation status and pattern. (A) Cumulative probability of developing a myeloid neoplasm in patients receiving a diagnosis of ICUS. (B) Distribution and cumulative incidence of progression to myeloid neoplasms according to the number of somatic mutations per patient. (C) Cumulative probability of progression to myeloid neoplasm according to mutation status. The red curve represents the probability of progression of patients with ICUS carrying 1 or more mutations in the set of genes analyzed (CCUS), whereas the blue curve reports the probability of progression of patients with ICUS without evidence of clonal hematopoiesis. (D) Cumulative probability of progression to myeloid neoplasm according to mutation pattern. The green curve represents the probability of progression of patients with CCUS showing mutation patterns highly predictive for myeloid neoplasm; the red curve represents the probability of progression of patients with low predictive mutation pattern, whereas the blue curve represents the probability of progression of patients with unmutated status.