Gal1 serum levels in cHL patients. Gal1 serum levels were assessed with a sandwich ELISA. (A) Gal1 levels in cHL patients and normal healthy donors (93.0 ± 56.5 ng/mL vs 36.9 ± 7.8 ng/mL, P < .0001). (B) Gal1 levels in patients on the risk-adapted clinical trials, HD13 (early-stage low-risk), HD14 (early-stage with risk factors), or HD18 (bulky localized or advanced-stage disease). (C) Gal1 levels in cHL patients with Ann Arbor stage I, II, III, or IV disease. Nominal P values are presented.