Figure 3
Figure 3. Summary of translocation events in myeloma. Translocations occur between the IGH locus and all main partner chromosomes through CSR in the germinal center. t(11;14) and t(14;20) subgroups also have other mechanisms of developing translocations through receptor revision in the germinal center or through DH-JH recombination at the early pro–B-cell stage.

Summary of translocation events in myeloma. Translocations occur between the IGH locus and all main partner chromosomes through CSR in the germinal center. t(11;14) and t(14;20) subgroups also have other mechanisms of developing translocations through receptor revision in the germinal center or through DH-JH recombination at the early pro–B-cell stage.

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