Abnormal H3K79me2 on MLL targets in the ML2 cell line. (A) H3K79me2 profiles of select MLL-target genes in MLL nonrearranged HL60 cells, MLL-AF9–positive MOLM-13 cells, and the MLL-AF6–positive ML2 cell line. (B) Level and distribution of H3K79me2 profiles around the transcription start site (TSS) of MLL core targets (cyan line) and MLL-AF6 direct targets (gold line) in the ML2 cell line. Genes with high levels of expression are depicted with the red line and genes with no expression are marked with the blue line.