Figure 2
Meta-analysis of GWAS in CEU, YRI, ASW, and ASN populations. (A) The Manhattan plot shows the meta-analysis results on GWAS of cellular susceptibility to cytarabine in 4 world populations (n = 523 individual samples). The highest-ranked SNP was rs7729269 (P = 3.67 × 10−7) in the gene MCC. (B) The plot shows P values from the meta-analysis of GWAS in CEU, YRI, ASW, and ASN populations for the top SNP associations with cytarabine log2 AUC in a specific region on chromosome 5. The colors, as indicated in the legend, denote the extent of LD between the SNPs; for this purpose, we use only the CEU reference population. The bottom panel illustrates the chromosomal region and genes that these SNPs fall on. The figure was made in LocusZoom.
