Top SNPs identified in LCLs are enriched for top associations with clinical phenotypes. Of the 33 SNPs tested that had an association with cytarabine-induced cytotoxicity in LCLs (P < 1 × 10⁻⁵), 18 were associated (P < .05) with cytarabine IC₅₀ in leukemia cells, day 22 MRD, RFS, OS, or TRM. The number of clinically validated SNPs is highly significant (P = .016) given the correlation structure of the genotypes evaluated and that of the phenotypes examined.