Serial transplantation and CNA profiling of TAM-derived cells from patients that did not develop ML-DS. (A) Serial transplantation assay using TAM cells from patient 2. Four attempts resulted in successful analysis in 1° recipients. CNAs with del(7p) and del(7q) were observed in 1 recipient (m2-2). No additional CNAs were observed in any other recipients. No engraftment was observed in 2° recipients. (B) Serial transplantation assay of TAM cells from patient 9. Five attempts resulted in successful analysis in 1° recipients. No additional CNAs were observed in any analyzed recipients, and no engraftment was observed in 2° recipients. NAA, no additional alteration; N/A, not assessed because of low cell count. *No engraftment.