Figure 2
![Figure 2. PARP1 inhibition suppresses SSA- as well as NHEJ-mediated translocations. (A) The p5pF translocation reporter system has puro and alu repeats (hatched and black boxes) flanking I-SceI sites on chromosomes 14 and 17. A translocation mediated by NHEJ reconstitutes a functional neo gene on der[17], whereas SSA reconstitutes both neo on der[17] and a functional puro gene on der[14]. SSA-mediated translocation events confer neo and puro resistance, whereas NHEJ translocations confer only neo resistance. (B) Frequencies of SSA- and NHEJ-mediated translocations are averages (± SEM) for 3 determinations. *P < .05; **P < .01. All results were normalized for survival in inhibitors.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/121/21/10.1182_blood-2012-10-460527/4/4359f2.jpeg?Expires=1735827288&Signature=q4DOnyoo7vFJeZ~qL2Q3BjsPAlhV8c3OOhjoAtIkc~CqdlLb9dodm3nisUyS4XydoxhlGOSYHx0vdS3PtaEf9LBuH-4kJ~bx0fmRH4oyI2JbCQNvaYzTOP8WVNvA3MqEyZp6wMqC~gjPcbiXr4o8GmKD2zBhVGB4cuNbVzG3tfc4HM1Rrz57A1uklFFVGFZeIlamEDWCkSiqKQ4xvpWe4QY93ssj1xJCYko6F8MRxJohn1nl5baReie9zXaaRUzPOKcDFO6jG19Ls-SAOmiswunK3qI4-udBfB2XWWL-RmqNUilO0rbLWqKxWLUkNnOB-u-cc9htO4NdjyZotjhkoA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
PARP1 inhibition suppresses SSA- as well as NHEJ-mediated translocations. (A) The p5pF translocation reporter system has puro and alu repeats (hatched and black boxes) flanking I-SceI sites on chromosomes 14 and 17. A translocation mediated by NHEJ reconstitutes a functional neo gene on der[17], whereas SSA reconstitutes both neo on der[17] and a functional puro gene on der[14]. SSA-mediated translocation events confer neo and puro resistance, whereas NHEJ translocations confer only neo resistance. (B) Frequencies of SSA- and NHEJ-mediated translocations are averages (± SEM) for 3 determinations. *P < .05; **P < .01. All results were normalized for survival in inhibitors.
