Olaparib represses chromosomal translocations induced by IR or VP16. (A) Representative metaphase spreads showing IR-induced dicentric and ring chromosomes. (B-C) Olaparib reduces IR-induced translocations in normal human WI38 fibroblasts and VP16-induced translocations in 32D murine hematopoietic progenitor cells. *P < .05; **P < .01, based on z values calculated from 135-192 metaphase spreads (B) or 103-248 metaphase spreads (C).