The effects of LIMK1 knockout on in vivo thrombosis and hemostasis. (A-B) FeCl₃-induced occlusive thrombosis in carotid arteries of LIMK1^−/− and wild-type (WT) mice. (A) Typical charts of FeCl₃-induced occlusive thrombosis in WT and LIMK1^−/− mice as indicated by carotid artery blood flow. (B) The occlusion times for each mouse are shown as squares (WT, n = 10) or triangles (LIMK1^−/−, n = 10). The horizontal bars represent the mean occlusion time (P = .0086, Student t test). (C) Tail bleeding times of each mouse are shown as squares (WT, n = 17) or triangles (LIMK1^−/−, n = 17). The horizontal bars represent the median bleeding time (P = .41, Mann-Whitney U test).