Cerebral blood flow continuously recorded after photochemically induced MCA damage: effect of the different drugs administered immediately after the induction of damage. (A) ALX-0081 5 mg/kg (shaded triangle) and 8.5 mg/kg (♢); (B) tirofiban 20 µg/kg bolus + 20 µg/kg over a 2-hour infusion (♦); (C) rtPA low dose of 0.032 mg intravenous bolus + 0.576 mg/kg over 30 minutes (○) and high dose of 0.1 mg intravenous bolus + 0.9 mg/kg over 30 minutes (●); (D) ALX-0081 5 mg/kg plus low-dose rtPA at 0.032 mg intravenous bolus + 0.576 mg/kg over 30 minutes (shaded square). (A-D) Vehicle (▪). Area over the curve (AOC) has been calculated for each treatment by using GraphPad Prism 4.0 for Windows software. (A) AOC: control = 14 487 ± 509; ALX-0081 5 mg/kg = 7445 ± 1216; ALX-0081 8.5 mg/kg = 4048 ± 542. (B) AOC: control = 14 487 ± 509; tirofiban = 10 507 ± 805. (C) AOC: control = 14 487 ± 509; rtPA low dose = 12 242 ± 1776; rtPA high dose = 5251 ± 949. (D) AOC: control = 14 487 ± 509; ALX-0081 + rtPA low dose = 7285 ± 1272. n = 5 per group.