Figure 4
Figure 4. Blood flow continuously recorded after photochemically induced MCA damage: effect of drugs administered 15 minutes and 1 hour after MCA occlusion. ALX-0081 at 5 mg/kg (shaded triangle), rtPA high dose at 0.1 mg/kg intravenous bolus + 0.9 mg/kg over 30 minutes (♦), rtPA low dose at 0.032 mg intravenous bolus + 0.576 mg/kg over 30 minutes (♢), ALX-0081 + rtPA low dose (●), rhADAMTS13 at 1 µg/body (○), ALX-0081 + rhADAMTS13 (□). (A-D) Vehicle (▪). AOC has been calculated for each treatment by GraphPad Prism 4.0 for Windows software. (A) AOC: control = 15 124 ± 1142, rtPA low dose = 14 087 ± 1558, ALX-0081 = 7946 ± 1132, ALX-0081 + rtPA = 10 200 ± 953. (B) AOC: control = 15 124 ± 1142, ALX-0081 = 14 418 ± 1140, rtPA = 9845 ± 859. (C) AOC: control = 15 124 ± 1142, rtPA low dose = 9854 ± 794, rtPA low dose + ALX-0081 = 12 350 ± 1126. (D) AOC: control = 15 191 ± 1521, rhADAMTS13 = 14 660 ± 968, rhADAMTS13 + ALX-0081 = 11 240 ± 1032. n = 5 per group.

Blood flow continuously recorded after photochemically induced MCA damage: effect of drugs administered 15 minutes and 1 hour after MCA occlusion. ALX-0081 at 5 mg/kg (shaded triangle), rtPA high dose at 0.1 mg/kg intravenous bolus + 0.9 mg/kg over 30 minutes (♦), rtPA low dose at 0.032 mg intravenous bolus + 0.576 mg/kg over 30 minutes (♢), ALX-0081 + rtPA low dose (●), rhADAMTS13 at 1 µg/body (○), ALX-0081 + rhADAMTS13 (□). (A-D) Vehicle (▪). AOC has been calculated for each treatment by GraphPad Prism 4.0 for Windows software. (A) AOC: control = 15 124 ± 1142, rtPA low dose = 14 087 ± 1558, ALX-0081 = 7946 ± 1132, ALX-0081 + rtPA = 10 200 ± 953. (B) AOC: control = 15 124 ± 1142, ALX-0081 = 14 418 ± 1140, rtPA = 9845 ± 859. (C) AOC: control = 15 124 ± 1142, rtPA low dose = 9854 ± 794, rtPA low dose + ALX-0081 = 12 350 ± 1126. (D) AOC: control = 15 191 ± 1521, rhADAMTS13 = 14 660 ± 968, rhADAMTS13 + ALX-0081 = 11 240 ± 1032. n = 5 per group.

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