Crystal structure of SH3:RGT complex. (A) Schematic diagram of c-Src activation mediated by integrin β3. It has been reported that integrin β3 can activated c-Src via the interaction of SH3:RGT.^19,36  The crystallographic characterization presented in this report is highlighted by an illustration box with a stereo diagram of SH3:RGT. The SH3 domain is shown as a diagram. The RGT peptide is shown in stick representation. The 2Fo-Fc electron density at the level of 0.5 σ is shown in blue. (B) Sequence alignment of the SH3 domains of Src family kinases. The secondary structural elements are annotated on top of the sequences. The residues that are in direct contact with the RGT peptide are highlighted with blue boxes. The highly and relatively conserved residues are indicated with “*” and “:,” respectively. The structural figure was prepared using Pymol.³⁷