The Structure of CLEC4M and the distribution of CLEC4M VNTR alleles in individuals with type 1 VWD and their families. (A) CLEC4M is organized into 4 domains: an N-terminal cytoplasmic domain, a neck region, and a CRD. The neck region is highly polymorphic, containing VNTR of a highly conserved 23-amino-acid sequence, with a range of 4 to 9 repeats. (B) The distribution of the CLEC4M VNTR alleles as seen in 491 participants with type 1 VWD and their family members is shown.