Copy number analysis of 7q derived from SNP arrays of leukemia samples with −7/del(7q) shows that CUX1 maps within the 2.17 Mb CDR at 7q22.1. RNA-sequencing data showed that CUX1 is expressed at haploinsufficient levels in −7/del(7q) leukemias and this is associated with a cell-cycle transcriptional gene signature. Haploinsufficiency of CUX1 gave human hematopoietic cells a significant engraftment advantage upon transplantation into immunodeficient mice. Adapted from Figure 1 and Figure 3A in the article by McNerney et al that begins on page 975.¹