Gata2 haploinsufficiency promotes leukemogenesis of 3q21q26 mice. (A) Schema of mating strategy. The numbers (percentages) of pups at weaning that bear the 4 possible genotypes is depicted. (B) Kaplan-Meier survival curves of WT (n = 22; median, not determined), Gata2^+/− (n = 22; median, not determined), 3q21q26 (n = 19; median, 345 days), and 3q21q26::Gata2^+/− (n = 15; median, 276 days) mice. (C) Representative smears of peripheral blood taken from leukemic 3q21q26 and 3q21q26::Gata2^+/− mice and age-matched healthy WT and Gata2^+/− mice. (D) White blood cell, red blood cell, and platelet counts in the peripheral blood of WT (n = 13), Gata2^+/− (n = 11), 3q21q26 (n = 15), and 3q21q26::Gata2^+/− (n = 14) mice. (E) Average spleen weights (left) from WT (bar 1 [n = 13]), Gata2^+/− (bar 2 [n = 11]), 3q21q26 (bar 3 [n = 15]), and 3q21q26::Gata2^+/− (bar 4 [n = 14]) mice. Representative spleens from WT, Gata2^+/−, leukemic 3q21q26, and 3q21q26::Gata2^+/− mice are shown in right panel. Scale bar, 1 cm. (F) Hematoxylin and eosin staining of the liver and lung from WT, Gata2^+/−, leukemic 3q21q26, and 3q21q26::Gata2^+/− mice. Parameters of the box plot are defined within the Statistical analysis paragraph in “Methods.” *P < .05; **P < .01.