Systemic treatment with recombinant IL-7/anti-IL-7 complexes equally enhances lymphatic drainage in the skin or WT and of RAG1^−/−mice. (A) WT and RAG1^−/− mice were treated intraperitoneally every other day for a total of 7 days with IL-7/anti–IL-7 complexes or PBS. On day 6, Evans blue dye was injected intradermally into the ears of mice. Animals were sacrificed on day 7 and ears were used for Evans blue quantification. (B-C) IL-7/anti–IL-7 complex–treated WT mice exhibited increased drainage function of dermal LVs upon intradermal injection of Evans blue. (B) Quantification of the total Evans blue dye present in the ear 16 hours after injection. (C) Representative pictures taken 16 hours after Evans blue injection. (D-E) IL-7/anti–IL-7 complex–treated RAG1^−/− mice exhibited increased drainage function of dermal LVs upon intradermal injection of Evans blue. (D) Quantification of the total Evans blue dye present in the ear 16 hours after injection. (E) Representative pictures taken 16 hours after Evans blue injection. Pooled data from a total of 10 mice/group are shown. **P < .01.