Prognostic significance of UGT2B17 mRNA expression and genotype in CLL. (A) Impact of high UGT2B17 mRNA expression (> 1.77 fold of healthy donors) on TFS and OS. (B) Illustration of UGT2B17 expression and TFS in IGHV mutated subgroup only. (C) Lack of gene dosage effect of UGT2B17 copy number and (D) Impact of UGT2B17 CNV on TFS and OS.