Figure 6
Effect of LYVE-1 on FGF2-induced lymphangiogenesis in vivo. Corneal lymphangiogenesis after implantation of pellets containing FGF-2 alone or FGF-2 and LYVE-1. (A) Corneal whole mount with LYVE-1+ lymphatic vessels induced by 80 ng FGF-2. (B) Corneal whole mount with LYVE-1+ lymphatic vessels induced by a combination of 80 ng FGF2 and 1 μg LYVE-1. (C-D) Details of panels A and B, respectively. (E) Quantitative analysis of corneal lymphangiogenesis induced by FGF2 or FGF2/LYVE-1 containing pellets (nFGF2 = 21, nFGF2/LYVE-1 = 20; P = .0008). Data represent mean ± SD.
