hFcγRI can trigger inflammatory arthritis in transgenic mice. (A-C) K/BxN PA in indicated mice injected with indicated mAbs (A-B, n = 3; C, n = 4). (D) Arthritis induced in anti-FcγRIV–treated hFcγRI^tg 5KO mice by K/BxN serum (n = 4) or 80 μg of purified K/BxN IgG1 (n = 3) or of purified K/BxN IgG2 (n = 4). (E) K/BxN PA in anti-FcγRIV–treated hFcγRI^tg 5KO mice injected with indicated liposomes (n = 3) or mAbs (n = 4). Data are representative of at least 2 independent experiments and are represented as means ± SEM. Statistical differences between curves (B-D) or for each time point (A,E) are indicated (for panel A, between the anti-FcγRIV– and the anti-FcγRIV + anti-hFcγRI.1–treated groups).