Prognostic value of immature adult T-ALL. (A) Top 50 differentially expressed genes between early immature and cortical/mature adult T-ALL. Genes in the heat map are shown in rows, and each individual sample is shown in 1 column. The scale bar shows color-coded differential expression from the mean in standard deviation units, with red indicating higher levels and blue lower levels of expression. (B) Gene Set Enrichment Analysis of genes associated with pediatric ETP leukemias in early immature vs cortical/mature adult T-ALLs. (C) Kaplan-Meier survival curves in adult T-ALL patients treated in ECOG clinical trial ECOG2993 with early immature vs cortical/mature gene expression signatures.