The downregulation of caspase-8 and caspase-10, and upregulation of oct3/4 and tgf-β1 in MSCs (ITP) upon THD modulation. Expression levels of MSCs pre- or postexposed to 0.5 μg/mL THD for 12 hours from 8 ITP patients and 9 healthy controls. Each dot denotes the relative quantity of caspase-8, caspase-10, c-myc, oct3/4, klf4, tgf-β1, p27, and p16 (panels A-H, respectively). Statistical results represent median with interquartile range. Differences between MSCs (ITP) and THD-MSCs (ITP) or MSCs (control) and THD-MSCs (control) were determined using the Wilcoxon matched-pairs test. *P < .05; **P < .01.